Shim-pack GIS HILIC is designed for Hydrophilic Interaction Liquid Chromatography (HILIC). It is chemically bonded with a diol group, which provides excellent peak shape for basic and neutral polar compounds. In addition, HILIC is a variation of normal phase mode. It is capable of using organic solvents mixed with water as mobile phase, while normal phase mode uses non-aqueous organic solvents. In HILIC, the higher the organic concentration in the solvents, the greater is the retention of highly polar compounds